By Eveline S. Litscher, Paul M. Wassarman
This ebook presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details on hand for the zona pellucida area protein relations, which influence pathologies corresponding to infertility, deafness, and melanoma. moreover it:
- Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
- Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
- Speculates as to the evolution of the ZP area and strength therapeutics for illnesses stemming from ZP area mutations
- Addresses mammalian and non-mammalian systems
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Extra resources for A Guide to Zona Pellucida Domain Proteins
1 mtggrlvall llvaaslglg qqphpepglp glqysydcgm rgmqlvvlpr pgrtirfkvv 61 defgnrfevn ncsicfhwvs aepqapavfs adykgchvle keghshltvf ieamlpdghv 121 evaqeavlic pkpghtwavg shqvppttps pttphalpfh lssahtfpip lylehslmlp 181 tpagpslgpg ptpavlaqve rwevdkpdav gshlpqewCq vasghipCiv qssskeaCeq PLACENTAL MAMMALS 31 241 agCCydsare vpCyygntat vqCfrngyfi lvvaqemala hritlanvhl ayaptrCppa 301 qktsafvifh vplthCgttv qvlgsqlfye nqlvsdidvr egpqgsitrd ssfrllvrCi 361 fnasdflpiq asifspplpa pvtqagplrl elriardetf ssfyeeedyp lvrllrepvh 421 vevrllqrtd pslvlelhqC watpsanpvq qpqwpllsdg Cpfkgdsyrt rvlaldrael 481 pfrshyqrft vatftfldsg aqralrglvy ffCsasaChp sgpetCsstC ssrtakrrrs 541 sgyhdgtpra ldivsspgpv gfqdshrqep tlestgsgrn snpkpllwvv llllaialvl 601 gigvfvglsq awahklregh rltdqaq ZP2: The polypeptide of ZP2 consists of 727 aa residues and has a ZPD (aa 380–644; highlighted) with 10 Cys residues (aa 381, 412, 433, 474, 554, 575, 624, 629, 639, 643; capitalized and underlined), followed by a CFCS (aa 648–651, RHRR; highlighted and underlined) and TMD (aa 698–717 highlighted).
Mouse ZP genes share TATAA boxes ≃30 bp upstream of the transcription start sites and E‐box sequences (CANNTG) that are involved in oocyte‐specific expression of ZP genes. At least two ovary‐specific DNA‐binding proteins, ZAP‐1 and OSP‐1, bind to promoters of mZP2 and 3. , firefly luciferase) to growing oocytes. Messenger‐ RNA encoding mouse ZP proteins is undetectable in non‐growing oocytes but appears in small oocytes that have entered the growth phase. For example, messenger‐RNA encoding mZP3 is undetectable in non‐growing oocytes but increases to ≃300,000 copies/oocyte in mid‐stage growing oocytes, falls to ≃240,000 copies/oocyte in fully‐grown oocytes, and decreases to undetectable levels in fertilized eggs (<1000 copies/egg).
Inhibition of zona pellucida gene expression by antisense oligonucleotides injected into mouse oocytes. J Biol Chem 270, 849–853 (1995). Wassarman PM. Fertilization in the mouse. I. The egg. ), Plenum Press, New York, pp. 151–165 (1991). Wassarman PM, Litscher ES. Influence of the zona pellucida of the mouse egg on folliculogenesis and fertility. Int J Dev Biol 56, 833–839 (2012). Wassarman PM, Litscher ES. Biogenesis of the mouse egg’s extracellular coat, the zona pellucida. Curr Topics Dev Biol 102, 243–266 (2013).